Recent Research on Sleep Disorders and Cannabidiol (CBD)
- Potential Effects Of Cannabidiol As A Wake-Promoting Agent
Over the last decades, the scientific interest in chemistry and pharmacology of cannabinoids has increased. Most attention has focused on ∆(9)-tetrahydrocannabinol (∆(9)-THC) as it is the psychoactive constituent of Cannabis sativa (C. sativa). However, in previous years, the focus of interest in the second plant constituent with non-psychotropic properties, cannabidiol (CBD) has been enhanced. Recently, several groups have investigated the pharmacological properties of CBD with significant findings; furthermore, this compound has raised promising pharmacological properties as a wake-inducing drug. In the current review, we will provide experimental evidence regarding the potential role of CBD as a wake-inducing drug.
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- Cannabidiol Can Improve Complex Sleep-Related Behaviors
Cannabidiol (CBD) is the main non-psychotropic component of the Cannabis sativa plant. REM sleepbehaviour disorder (RBD) is a parasomnia characterized by the loss of muscle atonia during REM sleep associated with nightmares and active behaviour during dreaming. This case series indicates that CBD is able to control the symptoms of RBD.
- Effects Of Acute Systemic Administration Of Cannabidiol On Sleep-Wake Cycle In Rats
The objective of this paper is to assess the effects on sleep of acute systemic administration of CBD. During the light period of the test day, the total percentage of sleep significantly increased in the groups treated with 10 and 40 mg/kg of CBD compared to placebo. REM sleep latency increased in the group injected with CBD 40 mg/kg and was significantly decreased with the dose of 10 mg/kg on the post-test day. There was an increase in the time of SWS in the group treated with CBD 40 mg/kg, although this result did not reach statistical significance. The systemic acute administration of CBD appears to increase total sleep time, in addition to increasing sleep latency in the light period of the day of administration.
- Effect Of Cannabidiol On Sleep Disruption
In this study, CBD efficiently blocked anxiety-induced REM sleep suppression, but had little effect on the alteration of NREM sleep. Conclusively, CBD may block anxiety-induced REM sleep alteration via its anxiolytic effect, rather than via sleep regulation per se.
- Effect Of Delta-9-Tetrahydrocannabinol And Cannabidiol On Nocturnal Sleep And Early-Morning Behavior In Young Adults
The effects of cannabis extracts on nocturnal sleep, early-morning performance, memory, and sleepiness were studied. Fifteen milligrams THC would appear to be sedative, while 15 mg CBD appears to have alerting properties as it increased awake activity during sleep and counteracted the residual sedative activity of 15 mg THC.
- Cannabidiol, A Constituent Of Cannabis Sativa, Modulates Sleep In Rats
Delta(9)-tetrahydrocannabinol (Delta(9)-THC) and cannabidiol (CBD) are two major constituents of Cannabis sativa. Delta(9)-THC modulates sleep, but no clear evidence on the role of CBD is available. In order to determine the effects of CBD on sleep, it was administered intracerebroventricular. Study finds that CBD induces alertness and might be of therapeutic value in sleep disorders such as excessive somnolence.
Information on Sleep Disorders
⇒ What Are Sleep Disorders?
Sleeping is one of the most important components of our life. It’s estimated that in your lifetime, you will sleep for a total of 26 years! With so much time dedicated to sleeping, sleep disorders can be extremely detrimental to your health. According to WebMD, sleeping fewer than 6 hours a night for an extended period of time is risky. In one study, people over the age of 45 who got less than 6 hours of sleep a night doubled their chances for stroke or heart attack and were also more likely to have heart failure.
Read 16 Surprising Effects of Sleep Deprivation
So how do we classify sleep? Sleep can be divided into two types: REM sleep and non-REM (NREM) sleep. Non-REM sleep has four stages of increasingly deep sleep. The first stage of sleep is the lightest, while stage 4 is the deepest.
During your normal sleep cycle, you rotate through these types and stages of sleep. However, if your sleep is repeatedly interrupted (i.e constantly waking up) and you cannot cycle normally through REM and NREM sleep, you are likely to feel exhausted, fatigued, and have trouble concentrating and paying attention while awake. Sleepiness can also put you at greater risk for car accidents, can negatively impact your sex drive, and put you at a risk for a number of different health problems. You can read more about the negative effects of sleep deprivation in the article 10 Surprising Effects of Lack of Sleep, featured on WebMD.
If you have trouble falling asleep or sleeping through the night without waking up constantly, if you struggle to wake up at all, or if you are constantly exhausted day after day, you may have a sleep problem. Fortunately, CBD oil has been shown to increase total sleep time, in addition to decreasing the onset of sleep. It has also been shown to control the symptoms of REM sleep-behavior disorder (RBD) and block anxiety-induced REM sleep alteration.