Recent Research on Multiple Sclerosis and Cannabidiol (CBD)
- Do Cannabis-Based Medicinal Extracts Have General Or Specific Effects On Symptoms In Multiple Sclerosis?
The objective was to determine whether a cannabis-based medicinal extract (CBME) benefits a range of symptoms due to multiple sclerosis (MS). A parallel group, double-blind, randomized, placebo-controlled study was undertaken in three centres, recruiting 160 outpatients with MS experiencing significant problems from at least one of the following: spasticity, spasms, bladder problems, tremor or pain. Spasticity VAS scores were significantly reduced by CBME (Sativex) in comparison with placebo (P- 0.001). There were no significant adverse effects on cognition or mood and intoxication was generally mild.
- Cannabidiol Provides Long-Lasting Protection Against The Deleterious Effects Of Inflammation In A Viral Model Of Multiple Sclerosis
Inflammation in the central nervous system (CNS) is a complex process that involves a multitude of molecules and effectors, and it requires the transmigration of blood leukocytes across the blood-brain barrier (BBB) and the activation of resident immune cells. Cannabidiol (CBD), a non-psychotropic cannabinoid constituent of Cannabis sativa, has potent anti-inflammatory and immunosuppressive properties. Findings highlight the anti-inflammatory effects of CBD in this viral model of MS and demonstrate the significant therapeutic potential of this compound for the treatment of pathologies with an inflammatory component.
- Meta-Analysis Of Cannabis Based Treatments For Neuropathic & Multiple Sclerosis-Related Pain
Debilitating pain, occurring in 50-70% of multiple sclerosis (MS) patients, is poorly understood and infrequently studied. This study summarizes the efficacy and safety data of cannabinoid-based drugs for neuropathic pain. It find cannabinoids including the cannabidiol/THC buccal spray are effective in treating neuropathic pain in MS.
- Cannabinoids In Multiple Sclerosis (CAMS) Study
This study is to test the effectiveness and long term safety of cannabinoids in multiple sclerosis (MS), in a follow up to the main Cannabinoids in Multiple Sclerosis (CAMS) study. This data provides limited evidence for a longer term treatment effect of cannabinoids.
- Therapeutic Action Of Cannabinoids In A Murine Model Of Multiple Sclerosis
Cannabinoids may act as immunosuppressive compounds that have shown therapeutic potential in chronic inflammatory disorders. At a histological level, cannabinoids reduced microglial activation, abrogated major histocompatibility complex class II antigen expression, and decreased the number of CD4+ infiltrating T cells in the spinal cord. Both recovery of motor function and diminution of inflammation paralleled extensive remyelination. Overall, the data presented may have potential therapeutic implications in demyelinating pathologies such as MS; in particular, the possible involvement of cannabinoid receptor CB2 would enable nonpsychoactive therapy suitable for long-term use.
- Cannabinoids Inhibit Neurodegeneration In Models Of Multiple Sclerosis
Multiple sclerosis is increasingly being recognized as a neurodegenerative disease that is triggered by inflammatory attack of the CNS. As yet there is no satisfactory treatment. Using experimental allergic encephalo myelitis (EAE), an animal model of multiple sclerosis, we demonstrate that the cannabinoid system is neuroprotective during EAE.
Information on Multiple Sclerosis
Multiple sclerosis (MS) is a disease in which your immune system attacks the protective sheath (myelin) that covers your nerves. Myelin damage disrupts communication between your brain and the rest of your body. Ultimately, the nerves themselves may deteriorate, a process that’s currently irreversible.
Signs and symptoms vary widely, depending on the amount of damage and which nerves are affected. Some people with severe MS may lose the ability to walk independently or at all, while others experience long periods of remission during which they develop no new symptoms.
There’s no cure for multiple sclerosis. However, treatments can help speed recovery from attacks, modify the course of the disease and manage symptoms.
Watch A Video On MS
The cause of multiple sclerosis is unknown. It’s believed to be an autoimmune disease, in which the body’s immune system attacks its own tissues. In MS, this process destroys myelin — the fatty substance that coats and protects nerve fibers in the brain and spinal cord.
Myelin can be compared to the insulation on electrical wires. When myelin is damaged, the messages that travel along that nerve may be slowed or blocked.
It isn’t clear why MS develops in some people and not others. A combination of factors, ranging from genetics to childhood infections, may play a role.