Cannabidiol Against Lung Cancer Cells

US National Library of Medicine

US National Library of Medicine

A recent study published by the National Institutes of Health has found that cannabinoids can increase a cancer cell’s susceptibility to cytolysis, which occurs when a cell bursts due to an imbalance.

“Cannabinoids have been shown to promote the expression of the intercellular adhesion molecule 1 (ICAM-1) on lung cancer cells as part of their anti-invasive and antimetastatic action. Using lung cancer cell lines (A549, H460) and metastatic cells derived from a lung cancer patient, the present study addressed the impact of cannabinoid-induced ICAM-1 on cancer cell adhesion to lymphokine-activated killer (LAK) cells and LAK cell-mediated cytotoxicity.”

“Cannabidiol (CBD), a non-psychoactive cannabinoid, enhanced the susceptibility of cancer cells to adhere to and subsequently lysed by LAK cells, with both effects being reversed by a neutralizing ICAM-1 antibody. Increased cancer cell lysis by CBD was likewise abrogated when CBD-induced ICAM-1 expression was blocked by specific siRNA or by antagonists to cannabinoid receptors (CB1, CB2) and to transient receptor potential vanilloid 1.”

This data suggest that the cannabinoid-induced ICAM-1 boost on lung cancer cells is responsible for the increased susceptibility of these cells to destruction by LAK cells. This represents an antitumor mechanism of cannabinoids.

Read More About CBD In Lung Cancer Cells Here

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